![]() Triglycerides, total cholesterol and HDL cholesterol were estimated by methods described by Foster, Zlatkis and Warnicle respectively. The parameters included under the head lipid profile were serum triglycerides (TG), serum total cholesterol (T Chol), serum low density lipoprotein cholesterol (LDL Chol) and serum high density lipoprotein cholesterol (HDL Chol) The serum was stored at 0–4☌ and lipid analysis was done within 24 hours of collection. 3–4 ml of blood was collected in plain sterile bulbs and serum separated by centrifugation. Children below 5 years were allowed water till 2 hours before the samples were drawn. The blood samples were obtained after an overnight fast of 10 hours. The subjects were divided into six equal groups viz. Children of those parents who had any evidence of the above ailment were not included in the study. ![]() Parents of these children were also studied for any evidence of coronary artery disease, hypertension or cerebrovascular accident. For infants and children the blood samples were collected at the Well Baby Clinic, those admitted for minor surgical procedure and healthy siblings of indoor patients. The blood sample for newborns were collected from umbilical cord in the labour room. The children were studied for anthropometry, blood sugar and lipid profile. The aim of the present study is to establish the normal levels of serum lipids in healthy children upto 12 years of age.ġ50 normal healthy children in the age group 0–12 years were included in the study. It is important to establish the diagnosis of hyperlipidemia at an early age, if these measures have to be effective. Beneficial effects of diet and drugs in lowering total cholesterol and LDL levels have been well documented. It has been estimated that 63% of the phenotype variation in serum cholesterol is genetically determined, whereas the remaining 37% is due to environmental influences such as diet. The extent of these lesions in young age is related to the levels of both total cholesterol and low density lipoprotein (LDL) but inversely related to the high density lipoprotein (HDL) levels. ![]() Fatty streaks appear in the endothelium of aorta by six months of age. Risk of coronary artery diesase rises steadily with serum cholesterol. There was no significant difference in values between male and female children.Ītherosclerosis has become the pathological hall mark of hypertension, coronary artery disease and cerebrovascular accident. These values increased to 158.7 ± 21.23 mg/dl, 60.7 ± 11.70 mg/dl, 80.3 ± 19.26 mg/dl, 86.7 ± 28.80 mg/dl in males and 161.6 ± 23.09 mg/dl 66.7 ± 8.75 mg/dl, 75.8 ± 20.26 mg/dl and 93.2 ± 44.09 mg/dl in females respectively between 10–12 years of age, The various lipid fractions were at the lowest level at birth and increased significantly during first year of life, there after showing a much slower rise in levels. The mean values ± SD for total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides were 70 ± 14.48 mg/dl, 35.1 ± 8.04 mg/dl, 23.8 ± 10.62 mg/dl and 50.9 ± 20.77 mg/dl respectively for male neonates and 71.8 ± 13.96 mg/dl, 34.6 ± 6.55 mg/dl, 25.5 ± 9.29 mg/dl and 57.2 ± 18.57 mg/dl respectively for female neonates. They were divided into six equal groups viz., newborns, 0–1 year, 1–4 years, 4–7 years, 7–10 years and 10–12 years. One hundred and fifty healthy children in the age group of 0–12 years were studied to establish normal levels of lipid profile.
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